Monday, 25 August 2014

Preparation and Evaluation of Controlled Release Matrix Pellets of Ketoprofen

Preparation and Evaluation of Controlled Release Matrix Pellets of Ketoprofen: Pellets are well accepted technique to control the drug release from the dosage form to improve bioavailability, reduce absorption difference in patients, reduce the dosing frequency and adverse effects during prolong treatment. The main objective of the present study is to prepare and evaluate controlled release pellets of Ketoprofen by extrusion sheronization method, with release rate retarding polymers using as carrier for oral administration in view to achieve oral controlled release of the drug and to protect the gastric mucous membrane from drug irritation. Ketoprofen is potent NSAID having anti-inflammatory, analgesic, antipyretic properties. It is readily absorbed from the gastrointestinal tract and peak plasma concentrations occur about 0.5–2 h after a dose, but it causes a certain irritation in the gastrointestinal mucous membrane and possesses a bitter taste and aftertaste. The half-life in plasma is about 2–3 hr. Preformulation studies performed were comply with the standards. Compatibility studies revealed there was no interaction between the drug and polymers. The various evaluation parameters were given the positive results. In-vitro dissolution studies were showed that the release of drug from pellets was optimum. It was also observed that drug release increases sharply as well as the release best fit to the zero order release kinetics.All the pellets were stable with respective storage condition.