Saturday, 11 October 2014

A Review on The Fabrication Methods Used in Nano Technology for The Fabrication of Nano Fillers Used in Electrical Apparatuses

A Review on The Fabrication Methods Used in Nano Technology for The Fabrication of Nano Fillers Used in Electrical Apparatuses: In this paper, a wide literature survey was done on the various fabrication methods used for the manufacture of nano fillers used in electrical apparatuses. The important characteristics, advantages, disadvantages of the various fabrication methods used for the manufacture of nano fillers were discussed. The applications of the various fabrication methods used for the manufacture of nano fillers were also discussed. This paper would be helpful for the young scientist and engineers to study about the important fabrication methods used for the manufacture of nano fillers used in the electrical insulation system. This would motivate the young scientist for their research work to invent nano electrical and electronic apparatuses.

Wednesday, 1 October 2014

Intellectual Capital: A Case Study of Power Loom Using Analytic Hierarchy Process

Intellectual Capital: A Case Study of Power Loom Using Analytic Hierarchy Process: The purpose of this paper is to identify the critical success factors of IC influencing the performance of power loom textiles, to evaluate their impact on the organizational performance and to find out the effect of these factors on the organizational performance of small and medium-sized enterprises (SMEs) in Maharashtra using AHP. The methodology adopted is factors are identified through the literature survey and finalization of these factors is done by taking the opinion of Experts in the Indian context. By cognitive map the relation between these factors is determined and cause and effect diagram is prepared. Then these factors are arranged hierarchically and tree diagram is prepared. A questionnaire was designed and distributed among the experts; data is collected. By using Expert choice software data is filled to quantify by pair wise comparison of these factors and are prioritized. The weights demonstrate several key findings: local and global priority reveals there is a substantial effect of the Human capital on the organizational performance. The work related experience contributes 34.21%, which has a greater impact on performance. Operational procedures or practices contribute 52% in order to improve the operational performance and hence organizational performance. Overall, the results showed the central role of the human capital is important. The research is subject to the normal limitations of AHP. The study is using perceptual data provided by Experts which may not provide clear measures of impact factors. However, this can be overcome using more experts to collect data in future studies. Interestingly, the findings here may be generalisable outside Maharashtra, India. AHP as an innovative tool for quantification of IC factors impacting on performance and improving operational and organizational performance in today’s dynamic manufacturing environment. The finding suggests the notion that these IC critical success factors (CSFs) are to be studied carefully and improvement strategy should be developed. Moreover, the study emphasizes the need to link priority of factors to organizational performance and improvement. The study integrates the CSFs of performance and its quantification by using AHP and its effect on performance of power loom textiles. Very few studies have been performed to investigate and understand this issue. Therefore, the research can make a useful contribution.

Monday, 29 September 2014

Effect of Node Movement on DSDV, AODV and DSR

Effect of Node Movement on DSDV, AODV and DSR: A Mobile Ad-Hoc Network (MANET) is a self-configuring network of mobile nodes connected by wireless links to form an arbitrary topology without the use of existing infrastructure. Each node participating in the network acts both as host and a router and must therefore is willing to forward packets for other nodes. Research in this area is mostly simulation based; Random waypoint is the commonly used mobility model in these simulations. In this paper we have compared the performance of DSDV, AODV and DSR for different node speeds. Experiment results illustrate that performance of the routing protocol varies across mobility and node density.

I10-Index – A New Metric to Measure Citable Content

Some researchers in the infancy stage of their careers seldom bother about impact factors, citable content and metrics such as i-index or h-index. All they need is some clarity on how the subject is going to impact their scope of work. Indexing the citations is no longer a prerogative of the statisticians because it is actually the authors and researchers who are responsible for producing citable manuscripts. Prolific writers do not need a mention as to what they need to do in order to produce citable literature. They understand the parameters that govern high quality content. The race for citation indices is now interesting. Apart from h-index by Hirsch, the g-index by Leo Egghe, we have the latest arrival………. CLICK HERE TO READ FULL ARTICLE

Saturday, 27 September 2014

A Review on the Basics of Earthing

A Review on the Basics of Earthing: This paper deals with the basic knowledge for engineers to study about the basic need of earthing, types and applications of earthing. In addition IE rule, recommended specification and factors affecting the earth resistivity were mentioned in this paper.

Friday, 26 September 2014

H-index – A Neat Calculation of Scholarly Work

What is the genesis of any scientific research? No prize for guessing as very few would contradict the purpose of any invention is always focused towards the betterment of human civilization. Developing a manuscript which could lead to the prototype for a new, innovative product is a consequence of thorough research and development.
How to evaluate the worth of a scientific research that could potentially lead to ground breaking discovery in the chosen field? The journal impact factor is the conventional approach of ranking journals in a sequential order of significance. However, this method has received a lot of criticism.
 What is H-index?
In 2005, Jorge E. Hirsch, a Professor of physics...... 
TO READ MORE CLICK HERE 

Monday, 22 September 2014

What is Impact Factor - A Brief Discussion

What is Impact Factor?
How would you segregate an average article from a whole bunch of informative pieces that appear relevant in every sense of word in a journal? Check the number of counts that goes in favour of the article. This implies the number of times the article has been repeatedly cited in Journal Citation Reports (JCR). In the 1920’s, science librarians used to count raw citations with the purpose of saving money and shelf-space. Of course, the aim was to determine which journals made the best bet in their respective fields. However, this approach only met with modest success.  When Eugene Garfield, the founder of the Institute for Scientific Information formulated the impact factor, the intention was absolutely clear – determine how ubiquitous the article is on the basis of citations it receives.

The Impact Factor – How does it work?

The impact factor is an objective measurement of a journal’s quality, expressed in terms of numerical figures which are easy to understand.  The impact factor is a parameter for highlighting the relative significance of a journal within its specific field.  It indicates the frequency with which an article appears in the JCR.
 The impact factor acts a measuring medium for the number of citations received by articles in a particular journal. If a published article is cited one time, it denotes an impact factor of 1.0. Similarly, if the article is cited two and half times, it implies an impact factor of 2.5. Journals with high impact factors are notable than those with low impact factors. Apart from listing impact factors, the JCR also does the job of listing and ranking the journals in reference to their defined fields.

Impact Factor – Why do we need it?

How can we evaluate journals without overlooking their volume and frequency with which they are published? A big journal often tends to outweigh the small journal in terms of citable content. Most of us would wonder as to what should be done to restore parity between big and small journals related to the same field.
 The Impact Factor comes into picture. It is an invaluable tool for evaluating journals. It offers a level playing ground for both big and small journals because it mitigates the scope for absolute citations which could have gone in favour of big journals. The impact factor also offsets the advantage that frequently published journals may have over less frequently issues ones or olden journals over the newly launched ones.
 The impact factor does not foster comparison across different fields because citations would vary in numbers. Citations received from the mathematicians are bound to be more than those received from the biologists. Journals with high impact factors are the first choice for many.  They are extensively endorsed by authors, researchers, readers, scholars and academic librarians. Publishing work in a leading journal with high impact factors can be a turning point in the career for budding scientists. Scholars and researchers can showcase their work in prominent journals to attract critical acclaim and recognition.

Impact Factor – How to Calculate?

For One year Impact Factor Calculation:

A = Total number of articles published in 2005 year = 212
B = Total number of citation achieved in 2006 year for the articles which was published in 2005 year = 200
Impact Factor = B / A = 200 / 212 = 0.943
For Five year Impact Factor Calculation:
 A = Total number of articles published in 2005-2010 year = 1132
B = Total number of citation achieved in 2011 year for the articles which was published between 2005-2010 year = 1452
Five Year Impact Factor = B / A = 1452 / 1132 = 1.282
Calculation Reference Link :  The Thomson Reuters Impact Factor

Tuesday, 16 September 2014

A Survey of Positivity to 4-Aminoquinoline among Primary, Post Primary and Tertiary Institution Students in Ado Ekiti, Ekiti State, Nigeria

A Survey of Positivity to 4-Aminoquinoline among Primary, Post Primary and Tertiary Institution Students in Ado Ekiti, Ekiti State, Nigeria: A survey of urine positivity to 4-aminoquinoline was carried out to examine the current status of the chloroquine in the treatment of malaria in Southwestern, Nigeria. Out of 352 students examined 352(61%) were positive using Dill-Glazko test. High occurrence was more among the primary school pupils (68%), than secondary (62%), and tertiary (47%). More female student (61%) used chloroquine than male (55%). Pupils in the age group 6-10years (26%) had the highest occurrence followed by 11-15years (16%), 16-20years (8%), 21-25years (5%), 1-5years (3%) and 26-30years (1%) respectively. Although, newer antimalarial drugs such as Atesunate/Arthemeter, Halofantrin etc have been introduced lately, more people in Ado-Ekiti still prefer Chloroquine for the treatment of malaria. This result of the study suggests that chloroquine is still the first line of drug for the treatment of malaria in Ekiti state, Southwestern Nigeria.

Monday, 15 September 2014

Anthelmintic Screening of Crude Extracts of Hygrocybe Parvula

Anthelmintic Screening of Crude Extracts of Hygrocybe Parvula: The World Health Organization estimates that a staggering two billion people harbor parasitic worm infections. Parasitic worms also infect livestock and crops, affecting food production with a resultant economic impact. Despite this prevalence of parasitic infections, the research on anthelmintic drug is poor. As per WHO, only few drugs are frequently used in the treatment of helminthes in human beings. Anthelmintic from the natural sources may play a key role in the treatment of this parasitic infections.In the present investigation, anthelmintic screening of crude extracts of Hygrocybe parvula. The present study aimed at the in-vitro evaluation of anthelmintic activity of various solvent extracts of fruiting bodies of H. parvula using at three different concentrations (25, 50 and 100mg/ml) respectively. The study involved the determination of time of paralysis (P) and time of death (D) of the worms. In view of this petroleum ether, chloroform and methanol extracts of fruiting bodies of H. parvula were evaluated separately for the activity on adult Indian earthworms, Pheretima posthuma, using Piperazine citrate as reference standards. The results indicated that the petroleum ether extract was more potent than the chloroform and methanol solvent extract. All extracts showed effective anthelmintic activity at 100mg/ml concentration.

Thursday, 11 September 2014

A Review on the Nano fillers used for electrical apparatuses

A Review on the Nano fillers used for electrical apparatuses: In this paper, a wide study was done on the various nano fillers used in electrical apparatuses. The important physical, chemical, thermal, mechanical and electrical properties of the nano fillers were discussed. The applications of the nano fillers were discussed. This paper would be helpful for the young scientist and engineers to study about the important nano fillers used in the electrical insulation system. This would motivate them for their research work to invent nano electrical and electronic apparatuses.

A Review on Fundamentals of HVDC Transmission

A Review on Fundamentals of HVDC Transmission: This paper deals with the basic knowledge for engineers to study about the need for HVDC transmission, applications, advantages, disadvantages, types and basic components of HVDC transmission. In addition, a review was given on the recent trends in HVDC transmission.

Tuesday, 2 September 2014

scholarlyoa.com a fake website by Jeffery Beall




We are not wrong to say that Jeffrey Beall is publishing bluffing on his website. He has written our company  name on his website. We ask him that why you have written our company name on your website… he said if I though I do. We ask him to remove our name instead of that he has written a note on his website… he is just trying to create problems for upcoming journals… We had also sent one of the recent review report on his mail id and ask him that please give your guideline on what basis you write our company’s name but he do not have any genuine reason for the same.

A full mail communication can be given on<http://journalsclub.com/Jeffrey-Beall.pdf>


He doesn’t want us to start such service or he may be supported by other who do not want journals club in this service area.

We would like to update you that we are also not bound with this service only. We are also working to serve academic people for indexing, editing & plagiarism in the future.

Jeffery Beall does not have any documentation for writing any journal name on his website. He also don’t have guideline to remove journal name from his website.

We try a lot, but he just said if I thought fit I will write and last but not list A librarian cannot judge a journal until he has good documentation for that.

Some international  people only emphasis on English language to create the value for themselves, but what we believe is that peer review process is the only important technical aspects to publish a technical documents online.

---------------------------------------------- UPDATES ---------------------------------------------------------





It was always interesting how people are getting to gather to earn money may be by using direct method or maybe by using an indirect method like this. We got the following two mails saying that we will help you for proof reading services. Akim John also claims, says that I think, I will be able to contact Jeffrey Beall and request the removal of Journal Clubs & Co. From his list.

As a director of this company, I just want to say that non English speaking country like India are not handicap as far as English proofreading is a concern. We are in discussion with various recruiting agencies, and soon we will be hiring a person for the same job. We don’t like to feed international people who contact us in a wrong way like one person is posting a post on his website blog and another is coming for service help. If this such kind of silly method was not used, then we may think about to hire a service from international people or firm.

Our aim is to serve students, authors & editorial board members with best quality services. We as a technical people are much more concern about technical aspects of articles through a peer review process.

I think this website http://scholarlyoa.com/ has been created to miss guide the researcher.











Monday, 25 August 2014

Gravimetric Determination and Antimicrobial Studies of The Co (Ii) With Schiff Bases Derived From Sulphathiazole and 2-Hydroxy, 1-Napthaldehyde

Gravimetric Determination and Antimicrobial Studies of The Co (Ii) With Schiff Bases Derived From Sulphathiazole and 2-Hydroxy, 1-Napthaldehyde: Gravimetric determination of the Co(II) with the 2-hydroxy,1-napthaldehyde Sulphathiazole. The synthesis of metal sulfanilamide compounds has received much attention due to the effective chemotherapeutic agents to be employed for the prevention and cure of bacterial infections in humans. The present works deals with the synthesis and preliminary characteristics of various Schiff bases as ligands. Schiff bases derived by the condensation 2-hydroxy,1-napthaldehyde with Sulphathiazole. After synthesis of such Schiff bases as ligands, Co+2 ion introduced with them by chelation. The chemical and physical properties of metal chelates evaluated. Antimicrobial properties the ligands and metal chelate of 2-hydroxy,1-napthaldehyde Sulphathiazole also evaluated.

Studies of Newly Synthesized Octahedral Copper Complexes Based on Coumarins Along With Their Antioxidant, Anti-Tubercular And Antimicrobial Activity Evaluation

Studies of Newly Synthesized Octahedral Copper Complexes Based on Coumarins Along With Their Antioxidant, Anti-Tubercular And Antimicrobial Activity Evaluation: Some newly heterochelates synthesized by reflux of 3-acetyl 4-hydroxy coumarin, Enrofloxacin and transition metal. 1H, 13C, IR and ESI Mass confirm the formation of ligand. The heterochelates were characterized on the basis of different spectroscopic techniques like IR studies and elemental analysis while the geometry of complexes was octahedral which is confirmed by electronic spectra analysis. The compounds were subjected to antimicrobial, antioxidant and anti-tubercular activity viewing using serial broth dilution method and Minimum Inhibitory Concentration (MIC) is determined.

Effect of Different Viscosity Grade of HPMC on Cefixime Trihydrate Sustained Release Matrix Tablet

Effect of Different Viscosity Grade of HPMC on Cefixime Trihydrate Sustained Release Matrix Tablet: The present work aims to study effect of different viscosity grade of HPMC on cefixime trihydrate sustained release matrix tablet with a view to prolong drug release in vivo and reduce frequency of dosing. Cefixime Trihydrate is an orally active third generation cephalosporin. It has plasma half-life of 3-4 hrs. It is active against Gram+ve as well as Gram-ve bacteria. The Sustained release matrix tablets were prepared by wet granulation method using various release retardant polymers like different grade of HPMC, Lactose, MCC, and PVP K-30. The granules were subjected to pre-compression and post-compression parameters and they were in the acceptable limits. The in vitro retardation of drug release from HPMC matrices in accordance with its different proportion and viscosity grade was HPMC K-100M>HPMC K-15M >HPMC K-4M with ratio of (1, 1.5, 2) individually in formulation F1-F9 and (0.5, 0.75, 1) ratio in F10-F12. Among various kinetic models drug release was found to best fit the case – II transport, Zero order release model. A drug-excipient interaction was performed by DSC and FTIR; results were shown that there was no interaction between drug and excipients used. After 3 months stability study at 400C/75% RH, formulations found to be stable. So as the viscosity and proportion of HPMC increases release rate from sustained release cefixime trihydrate matrix tablet decreases.

Stability Indicating HPLC Method Development for Estimation of Montelukast Sodium and Acebrophylline in Combined Dosage Form

Stability Indicating HPLC Method Development for Estimation of Montelukast Sodium and Acebrophylline in Combined Dosage Form: Analysis of pharmaceutical product is very important as it concerned with life. Combination of Montelukast sodium and Acebrophylline is used in bronchial asthama and allergic rhinitis. In this Research work, Montelukast sodium and Acebrophylline stock solution was subjected to acid and alkali hydrolysis, oxidation, thermal photolytic and thermal degradation. In this Stability-Indicating method sample was analyzed by reverse phase C18 column (Hibar Lichrospher® 100, RP-18e 5 μm, 250 mm L × 4.6 mm diameter in size) as stationary phase and Acetonitrile:Methanol (60:40 %v/v, pH 3.2 adjusted with O-phosphoric acid) as a mobile phase at a flow rate of 0.8ml/min. Quantification was achieved at 260 nm with PDA detector. Method was validated according to ICH Q2 R1 guideline. The retention time for Montelukast sodium and Acebrophylline was found to be 15.49 minute and 3.45 minute, respectively. The linearity for Montelukast sodium and Acebrophylline was obtained in the concentration range of 5-25 µg/ml and 100-500 µg/ml with mean accuracies of 99.49-100.81% and 99.45-100.51% respectively. Values of %RSD for Precision Study and Robustness was found < 2%. % label claim was found to be 99.23% for MTKT and 100.83% for ACBR. The developed method meets all the acceptance criteria for the validation of analytical method as per the ICH Q2 R1 guideline. The degraded product peaks were well resolved from the pure drug peak with significant difference in their retention-time values. A simple, precise and accurate stability indicating RP-HPLC method was developed for estimation of Montelukast sodium and Acebrophylline in combined Dosage form.

Preparation and Evaluation of Controlled Release Matrix Pellets of Ketoprofen

Preparation and Evaluation of Controlled Release Matrix Pellets of Ketoprofen: Pellets are well accepted technique to control the drug release from the dosage form to improve bioavailability, reduce absorption difference in patients, reduce the dosing frequency and adverse effects during prolong treatment. The main objective of the present study is to prepare and evaluate controlled release pellets of Ketoprofen by extrusion sheronization method, with release rate retarding polymers using as carrier for oral administration in view to achieve oral controlled release of the drug and to protect the gastric mucous membrane from drug irritation. Ketoprofen is potent NSAID having anti-inflammatory, analgesic, antipyretic properties. It is readily absorbed from the gastrointestinal tract and peak plasma concentrations occur about 0.5–2 h after a dose, but it causes a certain irritation in the gastrointestinal mucous membrane and possesses a bitter taste and aftertaste. The half-life in plasma is about 2–3 hr. Preformulation studies performed were comply with the standards. Compatibility studies revealed there was no interaction between the drug and polymers. The various evaluation parameters were given the positive results. In-vitro dissolution studies were showed that the release of drug from pellets was optimum. It was also observed that drug release increases sharply as well as the release best fit to the zero order release kinetics.All the pellets were stable with respective storage condition.

Development and Evaluation of Fast Dissolving Tablets of Flurbiprofen

Development and Evaluation of Fast Dissolving Tablets of Flurbiprofen: The aim of the investigation is to prepare the fast dissolving tablet of flurbiprofen. Flurbiprofen, a widely prescribed anti inflammatory analgesic drug belongs to BCS class II and exhibit low and variable oral bioavailability due to its poor solubility and dissolution rate. The objective of the present study is to develop flurbiprofen fast dissolving tablet formulations by direct compression method by forming its inclusion complex with β-cyclodextrin. The 9 batches were prepared by using super disintegrants. The tablet weight is 350mg.The clathrate is having 1:1 proportion. Inclusion complex of BCD with drug enhance its dissolution and also improve the taste Different super disintegrating agent like cross carmellose sodium, kyron T-314 and SSG in different proportion to enhance solubility of flurbiprofen. The method used was direct compression and directly compressible vehicle used was avicel PH 102, Mannitol was used to fill up the tablet volume and was also acts as sweetener. All the evaluations were performed to check the efficacy and effectiveness of tablet like disintegration time, hardness, friability, wetting time and in-vitro dissolution test. From all the evaluations data batch B6 which contain kyron T-314 as superd isintegrating agent with 15mg in each tablet was evaluated as optimized formula for the preparation of fast dissolving tablet of flurbiprofen.

Formulation and Evaluation of Sustained Release Matrix Tablets of Diltiazem Hydrochloride

Formulation and Evaluation of Sustained Release Matrix Tablets of Diltiazem Hydrochloride: The purpose of present investigation was to develop sustained release matrix tablet of highly water soluble drug diltiazem hydrochloride by wet granulation method by using different hydrophilic (HPMC K4M, HPMC K1M, HPMC K100 M, Na CMC, Na alginate) and different hydrophobic (Eudragit RSPO, Eudragit RLPO, Eudragit RS-100, Eudragit RL-100, Ethyl cellulose) polymers. A 32 full factorial design was applied. The concentration of HPMC K15M in mg (X1) and concentration of Eudragit RSPO in mg (X2) were selected as independent variables. The %CDR at the end of 3 hrs (Q3) and %CDR at the end of 12 hrs (Q12) were selected as dependent variables. The prepared tablets were evaluated for hardness, friability, drug content, In vitro drug release. FT-IR, DSC and physical compatibility study were conducted for drug, and drug excipient mixture for interactions if any. The results indicated that concentration of HPMC K15M (X1) and concentration of Eudragit RSPO (X2) significantly affected the %CDR at the end of 3 hrs (Q3) and %CDR at the end of 12 hrs (Q12). Regression analysis and numerical optimization were performed to identify the best formulation. Formulation F11 prepared with HPMC K15M (70 mg) & Eudragit RSPO (10 mg) was found to be the best formulation with % CDR 20.32% and 96.59% at the end of 3 hrs and 12 hrs respectively. Optimized batch F11 showed similarity factor f2 value 69.14.

Formulation Optimization and Evaluation of Orodispersible Tablets of an Antipsychotic Drug Using Solubility Enhancement Technique

Formulation Optimization and Evaluation of Orodispersible Tablets of an Antipsychotic Drug Using Solubility Enhancement Technique: The main objective of this study is to formulate oro dispersible tablets of Olanzapine and to complex Olanzapine with β-cyclodextrin (β-CD) and PVP K 30. Olanzapine is second generation atypical antipsychotic drug. Phase solubility studies demonstrated that addition of water soluble polymer PVP K 30 with β-CD further enhanced solubility of drug compared to β-CD without PVP K 30. Complex was characterized using infrared spectroscopy, differential scanning calorimetry, % drug release study, % drug content and saturated solubility study. A 32 full factorial design was applied to systematically optimize the drug disintegration time. The concentration of Croscarmellose Sodium (X1) and concentration of Kyron T 314 (X2) were selected as independent variables. The disintegration time (Y1) and wetting time (Y2) were selected as dependent variables. The prepared tablets were evaluated for hardness, friability, disintegration time, wetting time and In-vitro drug release. The different formulations showed disintegration time between 19 to 48 seconds. The results indicated that concentration of croscarmellose Sodium (X1) and concentration of Kyron T 314 (X2) significantly affected the disintegration time (Y1) and wetting time (Y2).Regression analysis and numerical optimization were performed to identify the best formulation. Formulation F18 prepared with Croscarmellose Sodium (4.47 %) & Kyron T 314 (3.73 %) was found to be the best formulation with disintegration time 20 sec, wetting time 26 sec and % drug release in 10 min 99.49%.

Development and Characterization of Transdermal Patch for Controlled Release of Fluocinolone Acetonide

Development and Characterization of Transdermal Patch for Controlled Release of Fluocinolone Acetonide: The purpose of this research was to design matrix type of transdermal patch of Fluocinolone acetonide. Polyvinyl pyrrolidone K-30 (PVP K-30) and polyvinyl alcohol (PVA) was used in fixed ratio of 2:5 throughout the study and was concluded from preliminary study. Single layer matrix was chosen for providing 24 hrs. of continuous release. Solvent casting method was used for preparation of patches. 3 level 2 factor full factorial designs was applied for optimization of batch for optimising amount of poly ethylene oxide ( Polyox WSR 1105) and Propylene Glycol (PG). The effects of polymer type, polymer ratio, permeation enhancer, plasticiser on drug release were evaluated by in-vitro release using treated cellophane paper by using Franz diffusion cell. In addition various other characterizations like appearance, folding endurance, tensile strength, % moisture content, % drug content, thickness, flatness was done. ANOVA for Response Surface Quadratic Model for % cumulative drug release and % moisture content responses applied and found significant for optimization. From the contour plot and over lay plot range of various amounts of PG and Polyox found to provide desired responses. Validity of equation was checked by checkpoint batch was true for present work.

Solubility Enhancement of Carbamazepine by Using Various Solubility Enhancement Techniques

Solubility Enhancement of Carbamazepine by Using Various Solubility Enhancement Techniques: Carbamazepine, structurally similar to dibenzine derivative is used in the treatment of Epilepsy and pain associated with trigeminal neuralgia. The drug is practically insoluble in water, so the rate of dissolution and bioavailability is less. In this investigation an attempt was made to enhance solubility of carbamazepine by solubility enhancement techniques like Solid dispersion, Inclusion complexation and Crystallization. For solid dispersion phase solubility studies were carried out using Mannitol, PEG 4000 and PVP K 30 and for Inclusion complexation Phase solubility studies were carried out using Complexol-HPTM and HPMC E 3. The solid dispersions, Inclusion complexes and Crystals were prepared by solvent evaporation method and characterized by FT-IR and differential scanning calorimetry (DSC) and evaluated for different parameters. The highest percent cumulative drug release was observed for CBI-2 batch of inclusion complex (97.38% in 60 min.)